| NCF1 |
| LOCUS ID | 653361 | ||||
| GENE_SYMBOL | NCF1 | ||||
| GENE NAME | nuclear factor, erythroid 2 | ||||
| SYNONYMNS | p45, NF-E2 | ||||
| CHROMOSOME | 12 | ||||
| HOMOLOGENE ID | 4491 | ||||
| SOURCE | MOUSE |
| PMIDs | 24072144 |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil DPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008] |
| OBSERVATION |
|---|
| 1. The NF-E2-related factor 2-mediated protection against diabetic nephropathy is, at least partially, through inhibition of TGF-beta 1 and reduction of extracellular matrix production. Studies show activation or overexpression of NRF2 inhibits the promoter activity of TGF- beta 1, whereas knockdown of NRF2 by small interfering RNA enhances TGF-beta 1 transcription.26 |