| NFE2L2 |
| LOCUS ID | 4780 | ||||
| GENE_SYMBOL | NFE2L2 | ||||
| GENE NAME | nuclear factor, erythroid 2-like 2 | ||||
| SYNONYMNS | NRF2, HEBP1 | ||||
| CHROMOSOME | 2 | ||||
| HOMOLOGENE ID | 2412 | ||||
| SOURCE | HUMAN, MOUSE |
| PMIDs | 25046864 |
| GENE SUMMARY |
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| This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015] |
| OBSERVATION |
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| 1. In all, Nrf2 could slow down DN progression by repression of TGF beta 1 in a c-Jun and SP1-dependent way. Our findings may provide novel clues for DN preventions and interventions in clinic. |