| NUCB1 |
| LOCUS ID | 4924 | ||||||
| GENE_SYMBOL | NUCB1 | ||||||
| GENE NAME | nucleobindin 1 | ||||||
| SYNONYMNS | NUC CALNUC | ||||||
| CHROMOSOME | 19 | ||||||
| HOMOLOGENE ID | 4507 | ||||||
| SOURCE | HUMAN |
| PMIDs | 28220836 |
| GENE SUMMARY |
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| This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010] |
| OBSERVATION |
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| 1. NUCB1 inhibits aggregation of islet-amyloid polypeptide associated with type 2 diabetes mellitus, a-synuclein associated with Parkinson?s disease, transthyretin V30M mutant associated with familial amyloid polyneuropathy, and A?42 associated with Alzheimer?s disease by stabilizing their respective protofibril intermediates. |