ARHGEF11
LOCUS ID9826
GENE_SYMBOLARHGEF11
GENE NAMERho guanine nucleotide exchange factor 11
SYNONYMNSGTRAP48,PDZ-RHOGEF
CHROMOSOME1
HOMOLOGENE ID11409
GENE SUMMARY
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]