GLP1R
LOCUS ID2740
GENE_SYMBOLGLP1R
GENE NAMEglucagon like peptide 1 receptor
SYNONYMNSGLP-1, GLP-1R, GLP-1-R
CHROMOSOME6
HOMOLOGENE ID1558
GENE SUMMARY
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes interlized in response to GLP-1 and GLP-1 alogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Altertive splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]