PPARG
LOCUS ID5468
GENE_SYMBOLPPARG
GENE NAMEperoxisome proliferator-activated receptor gamma
SYNONYMNSGLM1, CIMT1, NR1C3, PPARG1, PPARG2, PPARgamma
CHROMOSOME3
HOMOLOGENE ID7899
GENE SUMMARY
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additiolly, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Altertively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]