PPARGC1A
LOCUS ID10891
GENE_SYMBOLPPARGC1A
GENE NAMEperoxisome proliferator-activated receptor gamma,
SYNONYMNSLEM6, PGC1, PGC1A, PGC-1v, PPARGC1, PGC-1(alpha)
CHROMOSOME4
HOMOLOGENE ID7485
GENE SUMMARY
The protein encoded by this gene is a transcriptiol coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between exterl physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determition. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]