| SIRT1 |
| LOCUS ID | 23411 |
| GENE_SYMBOL | SIRT1 |
| GENE NAME | sirtuin 1 |
| SYNONYMNS | SIR2L1 |
| CHROMOSOME | 10 |
| HOMOLOGENE ID | 56556 |
| GENE SUMMARY |
|---|
| This gene encodes a member of the sirtuin family of proteins homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombition of rD. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Altertive splicing results in multiple transcript variants. [provided by RefSeq Dec 2008] |
| SIRT1 |
| LOCUS ID | 23411 |
| GENE_SYMBOL | SIRT1 |
| GENE NAME | sirtuin 1 |
| SYNONYMNS | SIR2L1 |
| CHROMOSOME | 10 |
| HOMOLOGENE ID | 56556 |
| GENE SUMMARY |
|---|
| This gene encodes a member of the sirtuin family of proteins homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombition of rD. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Altertive splicing results in multiple transcript variants. [provided by RefSeq Dec 2008] |