| TNFA |
| LOCUS ID | 7124 |
| GENE_SYMBOL | TNFA |
| GENE NAME | tumor necrosis factor |
| SYNONYMNS | DIF,TNFA,TNFSF2,TNLG1F,TNF-alpha |
| CHROMOSOME | 6 |
| HOMOLOGENE ID | 496 |
| GENE SUMMARY |
|---|
| This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008] |
| TNFA |
| LOCUS ID | 7124 |
| GENE_SYMBOL | TNFA |
| GENE NAME | tumor necrosis factor |
| SYNONYMNS | DIF,TNFA,TNFSF2,TNLG1F,TNF-alpha |
| CHROMOSOME | 6 |
| HOMOLOGENE ID | 496 |
| GENE SUMMARY |
|---|
| This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008] |