XRCC1
LOCUS ID7515
GENE_SYMBOLXRCC1
GENE NAMEX-ray repair complementing defective repair in Chi
SYNONYMNSRCC
CHROMOSOME19
HOMOLOGENE ID31368
GENE SUMMARY
The protein encoded by this gene is involved in the efficient repair of D single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with D ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in D processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]