RBP4
LOCUS ID5950
GENE_SYMBOLRBP4
GENE NAMEretinol binding protein 4, plasma
SYNONYMNSRDCCAS, MCOPCB10
CHROMOSOME10
HOMOLOGENE ID4908
SOURCEHUMAN
PMIDs20233518
GENE SUMMARY
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]

OBSERVATION
1. This study showed that RBP4 may be involved in the process of diabetic retinopathy and may be a novel biomarker for its diagnosis and treatment in diabetic patients.