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Diabetic Retinopathy

Go to Protective Genes for Retinopathy

Locus_Id Gene_Symbol Chromosome Homologene_Id Gene_Name Synonyms
17AAVS119NAadeno-associated virus integration site 1AAV
1636ACE1737351angiotensin I converting enzymeDCP, ICH, ACE1, DCP1, CD143, M
116ADCYAP118869adenylate cyclase activating polypeptide 1 (pituitary)PACAP
9370ADIPOQ33525adiponectin, C1Q and collagen domain containingACDC, ADPN, APM1, APM-1, GBP28
132ADK104891adenosine kinaseAK
133ADM11873adrenomedullinAM, PAMP
177AGER6883advanced glycosylation end product-specific receptorRAGE
57491AHRR549215aryl-hydrocarbon receptor repressorAHH, AHHR, bHLHe77
10598AHSA1148106AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)p38, AHA1, C14orf3
197AHSG31225alpha-2-HS-glycoproteinAHS, A2HS, HSGA, FETUA
231AKR1B17110647aldo-keto reductase family 1, member B1 (aldose reductase)AR, ADR, ALR2, ALDR1
207AKT1143785v-akt murine thymoma viral oncogene homolog 1AKT, PKB, RAC, CWS6, PRKBA, PK
213ALB4405albuminFDAH, ALBA, PRO0883, PRO0903, PRO1341
217ALDH21255480aldehyde dehydrogese 2 family (mitochondrial)ALDM, ALDHI, ALDH-E2
285ANGPT2822401angiopoietin 2ANG2, AGPT2
27329ANGPTL318499angiopoietin like 3ANL3, ANG-5, FHBL2, ANGPT5
51129ANGPTL41910755angiopoietin like 4NL2, ARP4, FIAF, HARP, PGAR, H
8639AOC3172770amine oxidase, copper containing 3HPAO, SSAO, VAP1, VAP-1
8539API5114809apoptosis inhibitor 5AAC11, AAC-11
335APOA11147900apolipoprotein A-I
338APOB2328apolipoprotein BFLDB, LDLCQ4, apoB-48, apoB-10
348APOE1930951apolipoprotein E
358AQP1768051aquaporin 1 (Colton blood group)CO, CHIP28, AQP-CHIP
361AQP41837507aquaporin 4MIWC, HMIWC2
58504ARHGAP2210141258Rho GTPase activating protein 22 RhoGAP2 RhoGap22
468ATF4221266activating transcription factor 4CREB2, TXREB, CREB-2, TAXREB67
627BDNF117245brain-derived neurotrophic factorANON2, BULN2
727C5920412complement component 5C5D,C5a,C5b,ECLZB,CPAMD4
847CAT1155514catalase
6347CCL2172245chemokine (C-C motif) ligand 2HC11, MCAF, MCP1, MCP-1, SCYA2
11126CD16015122CD160 moleculeNK1, BY55, NK28
9332CD16312128811CD163 moleculeM130, MM130
966CD591156386CD59 molecule, complement regulatory protein"16.3A5|EJ16|EJ30|EL32|G344|p1
54901CDKAL169830CDK5 regulatory subunit associated protein 1-like 1NA
1116CHI3L1155569chitinase 3 like 1GP39, ASRT7, GP-39, YKL40, CGP
1124CHN2731213chimerin 2BCH, CHN2-3, ARHGAP3, RHOGAP3
1268CNR167273cannabinoid receptor 1 (brain)CB1, CNR, CB-R, CB1A, CB1R, CA
81035COLEC121834248collectin subfamily member 12CLP1, NSR2, SRCL, SCARA4
1398CRK1781850v-crk avian sarcoma virus CT10 oncogene homologp38, CRKII
1401CRP1128039C-reactive protein, pentraxin-relatedPTX1
1490CTGF61431connective tissue growth factorCCN2, NOV2, HCS24, IGFBP8
1512CTSH1536159cathepsin HACC4, ACC5, CPSB, ACC-4, ACC-5
1536CYBBX68054cytochrome b-245, beta polypeptideCGD, NOX2, IMD34, AMCBX2, GP91
1557CYP2C1910110445cytochrome P450, family 2, subfamily C, polypeptide 19CPCJ, CYP2C, P450C2C, CYPIIC17
3491CYR6111194cysteine rich angiogenic inducer 61CCN1, GIG1, IGFBP10
23576DDAH118120dimethylarginine dimethylaminohydrolase 1DDAH, HEL-S-16
22943DKK1107689dickkopf WNT signaling pathway inhibitor 1SK, DKK-1
1803DPP423279dipeptidyl peptidase 4CD26 ADABP ADCP2 DPPIV TP103
1906EDN161476endothelin 1ET1, QME, PPET1, ARCND3, HDLCQ
1910EDNRB1389endothelin receptor type BETB, ET-B, ETB1, ETBR, ETRB, HSCR, WS4A, ABCDS, ET-BR, HSCR2
2022ENG992endoglinEND, HHT1, ORW1
2056EPO7624erythropoietinEP, MVCD2
64167ERAP2575183endoplasmic reticulum aminopeptidase 2LRAP, L-RAP
2065ERBB31220457erb-b2 receptor tyrosine kinase 3HER3, LCCS2, ErbB-3, c-erbB3,
2067ERCC1191501excision repair cross-complementing 1
2072ERCC4163836excision repair cross-complementation group 4RAD1|FANCQ, XPF
2167FABP4836067fatty acid binding protein 4 adipocyteaP2, ALBP, AFABP, A-FABP, HEL-S-104
100302740FAS-AS110FAS antisense RNA 1SAF, FASAS, FAS-AS
26269FBXO848137F-box protein 8FBS, DC10, FBX8
2864FFAR1193876free fatty acid receptor 1FFA1R, GPR40, GPCR40
26291FGF211910428fibroblast growth factor 21
257019FRMD3916012FERM domain containing 34.1O, P410, EPB41LO, EPB41L4O
79068FTO168053fat mass and obesity associatedALKBH9
2539G6PD 37906glucose-6-phosphate dehydrogenaseG6PD1
2597GAPDH12107053glyceraldehyde-3-phosphate dehydrogenaseG3PD, GAPD, HEL-S-162eP
2641GCG2136497glucagonGLP1,GLP2,GRPP
2668GDNF5433glial cell derived neurotrophic factorATF1|ATF2|HFB1-GDNF
2670GFAP171554glial fibrillary acidic proteinALXDRD
2678GGT12268450gamma-glutamyltransferase 1GGT, GTG, CD224, GGT, 1, D22S6
2696GIPR1920081gastric inhibitory polypeptide receptorPGQTL2
2740GLP1R61558glucagon like peptide 1 receptorGLP-1, GLP-1R, GLP-1-R
92344GORAB145113golgin, RAB6-interactingGO, NTKLBP1, SCYL1BP1
2876GPX1320155glutathione peroxidaGPXD, GSHPX1
2885GRB2171576growth factor receptor bound protein 2ASH, Grb3-3, MST084, NCKAP2, M
2944GSTM11121492glutathione S-transferase mu 1MU, H-B, GST1, GTH4, GTM1, MU-
2952GSTT12220235glutathione S-transferase theta 1
3048HBG211128032hemoglobin subunit gamma 2TNCY, HBG-T1
3077HFE688330hemochromatosisHH, HFE1, HLA-H, MVCD7, TFQTL2
3146HMGB113110676high mobility group box 1HMG1, HMG3, HMG-1, SBP-1
6927HNF1A12459HNF1 homeobox A HNF1 LFB1 TCF1 MODY3 TCF-1 HNF-1A IDDM20
266722HS6ST31389201heparan sulfate 6-O-sulfotransferase 3
3479IGF112515insulin like growth factor 1MGF, IGFI, IGF-I
3480IGF1R1530997insulin like growth factor 1 receptorIGFR, CD221, IGFIR, JTK13
3481IGF211510insulin like growth factor 2GRDF, IGF-II, PP9974, C11orf43
3605IL17A61651interleukin 17AIL17, CTLA8, IL-17, CTLA-8, IL
3606IL18111200interleukin 18IGIF, IL-18, IL-1g, IL1F4
3553IL1B2481interleukin 1 betaIL-1, IL1F2, IL1-BETA
386653IL311288541interleukin 31IL-31
3569IL67502interleukin 6HGF, HSF, BSF2, IL-6, IFNB2
3630INS11173insulinIDDM, ILPR, IRDN, IDDM1, IDDM2
3667IRS124049insulin receptor substrate 1HIRS-1
3673ITGA251662integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)BR, GPIa, CD49B, HPA-5, VLA-2,
3684ITGAM16526integrin, alpha M (complement component 3 receptor 3 subunit)CR3A, MO1A, CD11B, MAC-1, MAC1
3690ITGB31755444integrin beta 3GT, CD61, GP3A, BDPLT2, GPIIIa
3767KCNJ1111441potassium channel, inwardly rectifying subfamily J, member 11BIR, HHF2, PHHI, IKATP, TNDM3,
23028KDM1A132240lysine demethylase 1AAOF2, CPRF, KDM1, LSD1, BHC110
3897L1CAMX20128L1 cell adhesion moleculeS10 HSAS MASA MIC5 SPG1 CAML1 CD171 HSAS1 N-CAML1 NCAM-L1 N-CAM-L1
3950LECT251730leukocyte cell derived chemotaxin 2 chm2 chm-II
4025LPO1721240lactoperoxidaseSPO
56413LTB4R21410519leukotriene B4 receptor 2BLT2, NOP9, BLTR2, JULF2, KPG_
5598MAPK7172060mitogen-activated protein kinase 7BMK1, ERK4, ERK5, PRKM7
4153MBL210110436mannose-binding lectin (protein C) 2, solubleMBL, MBP, MBP1, MBPD, MBL2D, M
50639MBL3P10mannose-binding lectin family member 3, pseudogeneMBL, COLEC2
4313MMP2163329matrix metallopeptidase 2CLG4, MONA, CLG4A, MMP-2, TBE-
4318MMP9203659matrix metallopeptidase 9GELB, CLG4B, MMP-9, MANDP2
10573MRPL28164693mitochondrial ribosomal protein L28p15, MAAT1
4524MTHFR14349methylenetetrahydrofolate reductase (NAD(P)H)
55930MYO5C15135711myosin VC
4669NAGLU17222N-acetylglucosaminidase, alphaNAG, MPS3B, UFHSD, MPS-IIIB
4780NFE2L222412nuclear factor, erythroid 2 like 2NRF2, HEBP1
58157NGB1410942neuroglobin
4831NME217133879NME/NM23 nucleoside diphosphate kinase 2PUF, NDKB, NDPKB, NM23B, NDPK-
4842NOS11237327nitric oxide synthase 1 (neuronal)NOS, bNOS, nNOS, IHPS1, N-NOS,
4843NOS21755473nitric oxide synthase 2NOS, INOS, NOS2A, HEP-NOS
4846NOS37504nitric oxide synthase 3eNOS, ECNOS
4852NPY7697neuropeptide YPYY4
4925NUCB2113676nucleobindin 2NEFA, HEL-S-109
4934NYS37nystagmus 3, congenital autosomal dominantCN
142PARP111222poly(ADP-ribose) polymerase 1PARP, PPOL, ADPRT, ARTD1, ADPR
8050PDHX1155757pyruvate dehydrogenase complex component XE3BP, OPDX, PDX1, proX, DLDBP
5281PIGF231103phosphatidylinositol glycan anchor biosynthesis class F
57125PLXDC11710700plexin domain containing 1TEM3, TEM7
5433POLR2D237968polymerase (RNA) II (DNA directed) polypeptide DRBP4, RPB16, HSRBP4, HSRPB4
5444PON1768058paraoxonase 1ESA, PON, MVCD5
10631POSTN134730periostin, osteoblast specific factorPN, OSF2, OSF-2, PDLPOSTN
5468PPARG37899peroxisome proliferator-activated receptor gammaGLM1, CIMT1, NR1C3, PPARG1, PP
10891PPARGC1A47485peroxisome proliferator-activated receptor gamma, coactivator 1 alphaLEM6, PGC1, PGC1A, PGC-1v, PPA
11168PSIP1913242PC4 and SFRS1 interacting protein 1p52, p75, PAIP, DFS70, LEDGF,
5715PSMD9122106proteasome 26S subunit, non-ATPase 9p27, Rpn4
5743PTGS2131000prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)COX2, COX-2, PHS-2, PGG/HS, PG
5806PTX33268pentraxin 3TSG-14, TNFAIP5
5894RAF1348145Raf-1 proto-oncogene, serine/threonine kinaseNS5, CRAF, Raf-1, c-Raf, CMD1N
5947RBP132175retinol binding protein 1CRBP, RBPC, CRBP1, CRBPI, CRAB
5950RBP4104908retinol binding protein 4RDCCAS, MCOPCB10
5970RELA1132064v-rel avian reticuloendotheliosis viral oncogene homolog Ap65, NFKB3
6010RHO368068retina-specific pigment protein rhodopsin"OPN2|CSNBAD1", RP4
140823ROMO1207096reactive oxygen species modulator 1MTGM, MTGMP, C20orf52, bA353C1
6283S100A12148361S100 calcium binding protein A12p6, CAGC, CGRP, MRP6, CAAF1, M
6287SAA@11serum amyloid A1 clusterSAA, SAA4
6288SAA111128033serum amyloid A1SAA, PIG4, SAA2, TP53I4
1757SARDH95149sarcosine dehydrogenaseSAR, SDH, SARD, BPR-2, DMGDHL1
12SERPI314111129serpin peptidase inhibitor, clade A (alpha-1 antiproteise, antitrypsin), member 3ATF1|ATF2|HFB1-GDNF
5176SERPINF1171965serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1OI6, OI12, PEDF, EPC-1, PIG35
23411SIRT11056556sirtuin 1SIR2, SIR2L1, SIR2alpha
7871SLMAP331428sarcolemma associated proteinSLAP
23049SMG11656697SMG1 phosphatidylinositol 3-kinase-related kinaseATX, LIP, 61E3.4
6609SMPD111457sphingomyelin phosphodiesterase 1, acid lysosomalASM, NPD, ASMASE
9021SOCS3172941suppressor of cytokine signaling 3CIS3, SSI3, ATOD4, Cish3, SSI-3, SOCS-3
6647SOD121392superoxide dismutase 1 solubleALS|ALS1, IPOA
6648SOD26530superoxide dismutase 2, mitochondrialIPOB, MNSOD, MVCD6
6678SPARC531132secreted protein, acidic, cysteine-rich (osteonectin)ON, BM-40
6696SPP1420156secreted phosphoprotein 1OPN, BNSP, BSPI, ETA-1
5552SRGN102043serglycinPPG, PRG, PRG1
6750SST3819somatostatinSMST
6774STAT3177960signal transducer and activator of transcription 3 (acute-phase response factor)APRF, HIES, ADMIO
84447SYVN11132700synoviolin 1DER3, HRD1
6934TCF7L2107564transcription factor 7-like 2 (T-cell specific, HMG-box)TCF4, TCF-4
7054TH11307tyrosine hydroxylaseTYH, DYT14, DYT5b
7057THBS11531142thrombospondin 1TSP, THBS, TSP1, TSP-1, THBS-1
7076TIMP1X36321TIMP metallopeptidase inhibitor 1EPA, EPO, HCI, CLGI, TIMP
7078TIMP32236322TIMP metallopeptidase inhibitor 3SFD, K222, K222TA2, HSMRK222
7099TLR4941317toll-like receptor 4TOLL, CD284, TLR-4, ARMD10
7124TNF6496tumor necrosis factorDIF, TNFA, TNFSF2, TNLG1F, TNF-alpha
4982TNFRSF11B81912tumor necrosis factor receptor superfamily member 11bOPG, TR1, OCIF, PDB5
10381TUBB31668503tubulin, beta 3 class IIICDCBM, FEOM3, TUBB4, CDCBM1, C
51174TUBD1179443 tubulin delta 1 TUBD
10628TXNIP138186thioredoxin interacting proteinTHIF, VDUP1, HHCPA78, EST01027
7350UCP1422524uncoupling protein 1 (mitochondrial, proton carrier)UCP, SLC25A7
7351UCP2112516uncoupling protein 2 (mitochondrial proton carrier)UCPH, BMIQ4, SLC25A8
10911UTS214939urotensin 2UII, U-II, UCN2, PRO1068
7421VDR1237297vitamin D (1,25- dihydroxyvitamin D3) receptorNR1I1, PPP1R163
7422VEGFA62534vascular endothelial growth factor AVPF, VEGF, MVCD1
7424VEGFC43962vascular endothelial growth factor CVRP, Flt4-L, LMPH1D
7515XRCC11931368X-ray repair complementing defective repair in Chinese hamster cells 1RCC
84937ZNRF11641858zinc and ring finger 1, E3 ubiquitin protein ligaseNIN283