HPSE
LOCUS ID10855
GENE_SYMBOLHPSE
GENE NAMEheparase
SYNONYMNSHPA, HPA1,HPR1,HSE1,HPSE1
CHROMOSOME4
HOMOLOGENE ID68528
DiseaseDiabetic nephropathy
PMIDs22106160
GENE SUMMARY
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

OBSERVATIONS
Our results collectively underscore the crucial role of heparanase in the pathogenesis of DN and its potential as a highly relevant target for therapeutic interventions in patients with DN.