JAK2
LOCUS ID3717
GENE_SYMBOLJAK2
GENE NAMEJanus kinase 2
SYNONYMNSJTK10, THCYT3
CHROMOSOME9
HOMOLOGENE ID21033
DiseaseType 2 Diabetes
PMIDs24531222
GENE SUMMARY
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]

OBSERVATIONS
Our results suggest that adipocyte JAK2 plays a critical role in the regulation of adipocyte biology and whole-body metabolism. Targeting of the JAK-STAT pathway could be a novel therapeutic option for the treatment of obesity and type 2 diabetes.