PHD3
LOCUS ID112399
GENE_SYMBOLPHD3
GENE NAMEegl-9 family hypoxia inducible factor 3
SYNONYMNSPHD3, HIFPH3, HIFP4H3, EGLN3
CHROMOSOME14
HOMOLOGENE ID32531
DiseaseType 2 diabetes
PMIDs24037093
GENE SUMMARY
EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3) is a Protein Coding gene. Diseases associated with EGLN3 include?Hypoxia?and?Renal Cell Carcinoma. Among its related pathways are?Regulation of activated PAK-2p34 by proteasome mediated degradation?and?Pathways in cancer. GO annotations related to this gene include?oxidoreductase activity?and?oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is?EGLN1.

OBSERVATIONS
Thus, isoform-specific inhibition of Phd3 could be exploited to treat type 2 diabetes without the toxicity that could occur with chronic inhibition of multiple Phd isoforms.