SLC2A4
LOCUS ID6517
GENE_SYMBOLSLC2A4
GENE NAMEsolute carrier family 2 (facilitated glucose transporter), member 4
SYNONYMNSGLUT4
CHROMOSOME17
HOMOLOGENE ID74381
DiseaseType 2 diabetes
PMIDs23474483
GENE SUMMARY
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]

OBSERVATIONS
Taken together, a moderate increase in expression of GLUT4 is a good target for treatment of insulin resistance.