ACACB
LOCUS ID32
GENE_SYMBOLACACB
GENE NAMEacetyl-CoA carboxylase beta
SYNONYMNSACC2, ACCB, HACC275
CHROMOSOME12
HOMOLOGENE ID74382
microRNAsNANA
GENE SUMMARY
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. These data support a role for ACACB in obesity and potential roles for altered lipid metabolism in susceptibility to DN.23460794