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ACACB |
LOCUS ID | 32 | ||||||||||
GENE_SYMBOL | ACACB | ||||||||||
GENE NAME | acetyl-CoA carboxyla | ||||||||||
SYNONYMNS | ACC2, ACCB, HACC275 | ||||||||||
CHROMOSOME | 12 | ||||||||||
HOMOLOGENE ID | 74382 |
microRNAs | NA | NA |
GENE SUMMARY |
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Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidat |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. These data support a role for ACACB in obesity and potential roles for altered lipid metabolism in susceptibility to DN. | 23460794 |