ACE2
LOCUS ID59272
GENE_SYMBOLACE2
GENE NAMEangiotensin I converting enzyme 2
SYNONYMNSACEH
CHROMOSOMEX
HOMOLOGENE ID41448
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coroviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. These suggest that ACE2 plays a positive role in the protection against the pathogenesis of early renal damage. ACE2 expression is reduced gradually with the deepened degree of diabetic kidney damage, leading to the accumulation of AngII in the kidney, thereby increasing the renal injury.23963072
Cardiovascular1. Comparison of the type 2 diabetes patients with myocardial infarction versus those without-myocardial infarction, it was found that the frequencies of homozygote DD (41.2% versus 33.2%) and of allele D (64.7% versus 55.0%) increased remarkably; the difference was statistically significant (P<0.05).Allele D(RR=1.50) and genotype DD(RR=1.33) of ACE gene seemed to be a genetic risk factor for type 2 diabetes myocardial infarction.15192839