ADIPOQ
LOCUS ID9370
GENE_SYMBOLADIPOQ
GENE NAMEadiponectin, C1Q and collagen domain containing
SYNONYMNSACDC, ADPN, APM1, APM-1, GBP28, ACRP30, ADIPQTL1
CHROMOSOME3
HOMOLOGENE ID3525
microRNAsNANA
GENE SUMMARY
This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Serum total adiponectin and HMW adiponectin were found to be positively correlated with the severity of retinopathy and nephropathy but not with neuropathy in T2DM. 2. These data suggest that the GG genotype at rs2241766 is implicated in the pathogenesis of risk for diabetic nephropathy defined as UACR greater than 30 mg/day in patients with T2DM.17970779 , 23260797
Cardiovascular1. It is likely that the G allele of the ADIPOQ G276T polymorphism is a susceptibility allele for CVD in Japanese type 2 diabetic patients, especially when they accompany obesity. 2. SNP of ADIPOQ +276G>T should be related to susceptibility to glucose metabolism, while indirectly to lipid metabolism and fat-related cardiovascular damage.22138143, 26884098
Retinopathy1. In Asian Indians with type 2 diabetes, serum adiponectin levels are associated with microvascular complications and also with the severity of retinopathy. 2. Serum total adiponectin was found to have increased in the advanced stages of diabetic retinopathy. 3. Adiponectin concentrations are correlated with DR; however, the relationship between adiponectin concentrations and DR needs more in-depth investigations with larger sample sizes.25445230 , 17970779 , 24534238 , 22468045
Atherosclerosis1. Mutations in different regions of adiponectin gene have been reported to be associated with obesity, atherosclerosis and type 2 diabetes mellitus. A positive association has been found between SNP45 T > G and type 2 diabetes in the study population (P = 0.010, OR = 3.797, 95% CI = 1.312-10.983). Therefore, SNP45T > G in adiponectin gene may be one of the risk factors for type 2 diabetes-This study suggests that the GG genotype at ACDC SNP45 is associated with the presence of CAP and may contribute to atherosclerosis in type 2 diabetes mellitus.18191060
Neuropathy1. Regression analysis revealed adiponectin to be associated with microvascular disease (presence of neuropathy and/or retinopathy and/or nephropathy) (OR1.44, 95% CI1.01-2.06, p=0.049) even after adjusting for age, gender, BMI, HbA1c, diabetes of duration, serum cholesterol and triglycerides, hypertension and medication status.25445230