ADK
LOCUS ID132
GENE_SYMBOLADK
GENE NAMEadenosine kinase
SYNONYMNSAK
CHROMOSOME10
HOMOLOGENE ID4891
microRNAsNANA
GENE SUMMARY
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. Here we demonstrate that AKI-enhanced adenosine signaling provides protection from DR in mice23770229