AHSA1
LOCUS ID10598
GENE_SYMBOLAHSA1
GENE NAMEAHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
SYNONYMNSp38, AHA1, hAha1, C14orf3
CHROMOSOME14
HOMOLOGENE ID8106
microRNAsNANA
GENE SUMMARY
NA

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Chronic exposure of human mesangial cells to high glucose environments activates the p38 MAPK pathway. The activity of AP-1, a transcription factor complex that regulates several genes involved in diabetic nephropathy, is reversed when the p38 MAPK pathway is inhibited. These findings suggest the p38 MAPK pathway may be an important pathway involved in diabetic complications.11532081
CardiovascularThere is increasing evidence that p38 MAPK plays a significant role in diabetic cardiomyopathy, including the regulation of diabetic complications such as cardiac hypertrophy, fibrosis, and apoptosis.27376265
Retinopathy1. p38 MAPK plays an important role in diabetes-induced inflammation in the retina, and inhibition of p38 MAPK offers a novel therapeutic approach to inhibiting the development of early stages of diabetic retinopathy and other complications of diabetes.20071676