ALB
LOCUS ID213
GENE_SYMBOLALB
GENE NAMEalbumin
SYNONYMNSFDAH, ALBA, PRO0883, PRO0903, PRO1341
CHROMOSOME4
HOMOLOGENE ID405
microRNAsmiR-19226881255
GENE SUMMARY
Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Urinary albumin (ALB) has been measured as a marker for the early detection of diabetic nephropathy.These results indicate that ALB in such patients is susceptible to structural changes due to disease-induced urinary factors and, thus, their urine contains ALB with an altered reactivity to antibody.19317217
Atherosclerosis1. In addition, inflammatory cytokine levels were decreased only in azelnidipine group which possibly explains such beneficial effects of azelnidipine on urinary albumin excretion and carotid atherosclerosis.26388951
Neuropathy1. In addition, the PS of gALB isolated from patients with diabetic polyneuropathy was significantly increased (P less than 0.0001) compared to the PS for ALB isolated from the same patients.1549585
Retinopathy1. Insulin therapy and the GA/HbA1c ratio were significant independent variables for diabetic retinopathy.29649417