| ALDH1A1 |
| LOCUS ID | 216 | ||||||||||
| GENE_SYMBOL | ALDH1A1 | ||||||||||
| GENE NAME | aldehyde dehydrogena | ||||||||||
| SYNONYMNS | ALDC, ALDH1, HEL-9, HEL12, PUMB1, ALDH11, RALDH1, | ||||||||||
| CHROMOSOME | 9 | ||||||||||
| HOMOLOGENE ID | 110441 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show tha |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Retinopathy | 1. Recent evidence has suggested that M?ller glia dysfunction has a critical role in the pathogenesis of diabetic retinopathy. downregulation of ALDH1a1 may contribute to retinal M?ller glia accumulation of FDP-lysine adducts in diabetes. | 27618414 |