ALDH1A1
LOCUS ID216
GENE_SYMBOLALDH1A1
GENE NAMEaldehyde dehydrogenase 1 family, member A1
SYNONYMNSALDC, ALDH1, HEL-9, HEL12, PUMB1, ALDH11, RALDH1,
CHROMOSOME9
HOMOLOGENE ID110441
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. Recent evidence has suggested that M?ller glia dysfunction has a critical role in the pathogenesis of diabetic retinopathy. downregulation of ALDH1a1 may contribute to retinal M?ller glia accumulation of FDP-lysine adducts in diabetes.27618414