| ALOX12 |
| LOCUS ID | 239 | ||||||||||||||||
| GENE_SYMBOL | ALOX12 | ||||||||||||||||
| GENE NAME | arachidonate 12-lipo | ||||||||||||||||
| SYNONYMNS | LOG12, 12-LOX, 12S-LOX | ||||||||||||||||
| CHROMOSOME | 17 | ||||||||||||||||
| HOMOLOGENE ID | 560 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmos |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. ALOX12 gene polymorphism is associated with all-cause and cardiovascular mortality in diabetic nephropathy. | 29196930 |
| 1. ALOX12 gene polymorphism is associated with all-cause and cardiovascular mortality in diabetic nephropathy. | 29196930 | |
| Cardiovascular | 0 |