ALOX12
LOCUS ID239
GENE_SYMBOLALOX12
GENE NAMEarachidonate 12-lipoxygenase, 12S type
SYNONYMNSLOG12, 12-LOX, 12S-LOX
CHROMOSOME17
HOMOLOGENE ID560
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. ALOX12 gene polymorphism is associated with all-cause and cardiovascular mortality in diabetic nephropathy.29196930
1. ALOX12 gene polymorphism is associated with all-cause and cardiovascular mortality in diabetic nephropathy.29196930
Cardiovascular