ALOX5
LOCUS ID240
GENE_SYMBOLALOX5
GENE NAMEarachidonate 5-lipox
SYNONYMNS5-LO, 5LPG, LOG5, 5-LOX
CHROMOSOME10
HOMOLOGENE ID561
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory an

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. The arachidonate 5-lipoxygenase (ALOX5) pathway has been implicated in chronic inflammatory disease which may be influenced by vitamin D due to vitamin D response elements (VDRE). 30521849
Insulin resistance and inflammation1. ALOX5 and ALOX5AP expression is increased in humans and rodents with obesity and insulin resistance.27207555