AMBP
LOCUS ID259
GENE_SYMBOLAMBP
GENE NAMEalpha-1-microglobulin/bikunin precursor
SYNONYMNSA1M, HCP, ITI, UTI, EDC1, HI30, ITIL, IATIL, ITILC
CHROMOSOME9
HOMOLOGENE ID1234
microRNAsNANA
GENE SUMMARY
This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteinsalpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a Urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Label-free quantitative comparison of DN urinary exosomes vs control group and SRM further validation, resulted in the discovery of a panel of three proteins (AMBP, MLL3 and VDAC1) which changes in DN, opening a new field of research focused to improve diagnosis and follow-up of this pathology.24211404