ANG
LOCUS ID283
GENE_SYMBOLANG
GENE NAMEangiogenin, ribonuclease, Rse A family, 5
SYNONYMNSALS9, RAA1, HEL168, RSE4, RSE5
CHROMOSOME14
HOMOLOGENE ID74385
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Altertive splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, Rse A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Angiotensin (ANG)-(1-7) is known to attenuate diabetic nephropathy; 2. Chronic ANG-(1-7) treatment exerts a renoprotective effect in ZDF associated with a reduction of SBP, oxidative stress, and inflammatory markers. Thus ANG-(1-7) emerges as a novel target for treatment of diabetic nephropathy.22492942