ANGPTL4
LOCUS ID51129
GENE_SYMBOLANGPTL4
GENE NAMEangiopoietin-like 4
SYNONYMNSNL2, ARP4, FIAF, HARP, PGAR, HFARP, TGQTL, UNQ171, pp1158, ANGPTL2
CHROMOSOME19
HOMOLOGENE ID10755
microRNAsNANA
GENE SUMMARY
This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The upregulation of ANGPTL2 in diabetic glomerulopathy shows a close relationship to abnormal microvasculature and endothelial inflammation. ANGPTL2 may play an important role in the pathogenesis of diabetic glomerulopathy.17347581
Retinopathy1. ANGPTL4 was induced by high glucose in RPE cells and exhibited potent angiogenic activity on RE cells. Our are unique and may potentially add a new candidate to the long list of molecules involved in diabetic retinopathy23387337