AOC3
LOCUS ID8639
GENE_SYMBOLAOC3
GENE NAMEamine oxidase, copper containing 3
SYNONYMNSHPAO, SSAO, VAP1, VAP-1
CHROMOSOME17
HOMOLOGENE ID2770
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. VAP-1 inhibition might be beneficial in the treatment of DR.19635478