APC
LOCUS ID324
GENE_SYMBOLAPC
GENE NAMEadenomatous polyposis coli
SYNONYMNSGS, DP2, DP3, BTPS2, DP2.5, PPP1R46
CHROMOSOME5
HOMOLOGENE ID30950
microRNAsNANA
GENE SUMMARY
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Decreased APC levels in patients with type 2 diabetes may serve as a biomarker to indicate the early development of diabetic nephropathy.24660539
Atherosclerosis1. These results suggest that decreased APC generation is associated with vascular atherosclerotic changes in Type 2 diabetic patients.17971179