API5
LOCUS ID8539
GENE_SYMBOLAPI5
GENE NAMEapoptosis inhibitor 5
SYNONYMNSAAC11, AAC-11
CHROMOSOME11
HOMOLOGENE ID4809
microRNAsNANA
GENE SUMMARY
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic D fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple altertively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes.25819896