APOC3
LOCUS ID345
GENE_SYMBOLAPOC3
GENE NAMEapolipoprotein C-III
SYNONYMNSHALP2, APOCIII
CHROMOSOME11
HOMOLOGENE ID81615
microRNAsNANA
GENE SUMMARY
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. In addition, combinations of genotypes [APOE epsilon3/epsilon3 and LPL 447X+ (OR = 0.56), APOC3 CC and LPL 447X+ (OR = 0.31), APOE epsilon3/epsilon3 and APOC3 CC (OR = 0.61] were protective for DN compared with the most common combination of the respective polymorphisms.16813599
Cardiovascular1. The combination of these roles makes apoC-III an important therapeutic target for the management and prevention of CVD.25692924