APOL1
LOCUS ID8542
GENE_SYMBOLAPOL1
GENE NAMEapolipoprotein L1
SYNONYMNSAPOL, APO-L, FSGS4, APOL-I
CHROMOSOME22
HOMOLOGENE IDNA
microRNAsNANA
GENE SUMMARY
This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. APOL1 nephropathy risk variants are associated with altered high-density lipoprotein profiles in African Americans.26152403
Cardiovascular1. Although the APOL1 variants are not common in the mixed ancestry population of South Africa, the study does provide an indication that APOL1 variants may play a role in conferring an increased risk for renal and cardiovascular risk in this population.26112018