APPL1
LOCUS ID26060
GENE_SYMBOLAPPL1
GENE NAMEadaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
SYNONYMNSAPPL, DIP13alpha
CHROMOSOME3
HOMOLOGENE ID32143
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin siglling and insulin siglling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. In , in the experimental high glucose condition, APPL1 acts as a protective factor against podocytes injury through regulating AMPK sigling, and may be a new therapy target for diabetic nephropathy.26261560
Atherosclerosis1. a potential role of adiponectin/APPL1 signaling in mediating the effect of incretin in the prevention of atherosclerosis progression or plaque vulnerability in T2DM.27771154