AQP5
LOCUS ID362
GENE_SYMBOLAQP5
GENE NAMEaquaporin 5
SYNONYMNSPPKB, AQP-5
CHROMOSOME12
HOMOLOGENE ID20398
microRNAsNANA
GENE SUMMARY
Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmory secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Consistently, AQP5 is expressed in none of 15 normal controls, but in all of 17 kidney biopsies from patients with diabetic nephropathy. 2. ?In particular, uAQP5 levels seem to better discriminate DN from NDN patients and may represent a potential novel noninvasive biomarker for the diagnosis and follow-up of DN patients.?23326416, 28246612