| AR |
| LOCUS ID | 367 | ||||||||||
| GENE_SYMBOL | AR | ||||||||||
| GENE NAME | androgen receptor | ||||||||||
| SYNONYMNS | KD, AIS, AR8, TFM, DHTR, SBMA, HYSP1, NR3C4, SMAX1, HUMARA | ||||||||||
| CHROMOSOME | X | ||||||||||
| HOMOLOGENE ID | 28 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functiol domainsthe N-termil domain, D-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segmen |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. The C-106T polymorphism in the AR gene is a risk factor for development of diabetic nephropathy in type 2 diabetes in patients with poor glycaemic control. | 15637423 |