| Retinopathy | 1. Electronic validation and diagnostic value analysis of the identified DEGs [cytokine inducible SH2 containing protein (CISH), SR?related CTD associated factor 11 (SCAF11), estrogen receptor 1 (ESR1), Rho GTPase activating protein 25 (ARHGAP25), major histocompatibility complex, class II, DR ?4 (HLA?DRB4) and interleukin 23 subunit ? (IL23A)] was performed in the GEO dataset. Compared with the normal control group, a total of 1,467 DEGs with P<0.05 were identified in children with T1D. CISH and SCAF11 were determined to be the most up? and downregulated genes, respectively. Heterogeneous nuclear ribonucleoprotein D (HNRNPD; degree=33), protein kinase AMP?activated catalytic subunit ?1 (PRKAA1; degree=11), integrin subunit ?4 (ITGA4; degree=8) and ESR1 (degree=8) were identified in the PPI network as high?degree genes. ARHGAP25 (degree=12), HNRNPD (degree=10), HLA?DRB4 (degree=10) and IL23A (degree=9) were high?degree genes identified in the TF?target network. | 30942443 |
