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ATF4 |
LOCUS ID | 468 | ||||||||||||||||
GENE_SYMBOL | ATF4 | ||||||||||||||||
GENE NAME | activating transcrip | ||||||||||||||||
SYNONYMNS | CREB2, TXREB, CREB-2, TAXREB67 | ||||||||||||||||
CHROMOSOME | 22 | ||||||||||||||||
HOMOLOGENE ID | 1266 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene encodes a transcription factor that was originally identified as a widely expressed mammalian D binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of D-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like p |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. Therefore, our demonstrate that the ER stress-regulated ATF4/p16 pathway is involved in the premature senescence of RTECs during diabetic nephropathy (DN) progression. | 25567807 |
Retinopathy | 1. Taken together, our suggest a critical role of ATF4 in the regulation of MCP-1 production in retinal and brain microvascular endothelial cells, which may contribute to inflammation-related endothelial injury in diseases such as diabetic retinopathy. | 25914608 |
Neuropathy | 1. ER stress-related proteins GRP78, p-PERK, ATF4 and CHOP were also inhibited by AS-IV in kidney of DN rats. | 30396095 |