ATF4
LOCUS ID468
GENE_SYMBOLATF4
GENE NAMEactivating transcription factor 4
SYNONYMNSCREB2, TXREB, CREB-2, TAXREB67
CHROMOSOME22
HOMOLOGENE ID1266
microRNAsNANA
GENE SUMMARY
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian D binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of D-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a D binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Therefore, our demonstrate that the ER stress-regulated ATF4/p16 pathway is involved in the premature senescence of RTECs during diabetic nephropathy (DN) progression.25567807
Retinopathy1. Taken together, our suggest a critical role of ATF4 in the regulation of MCP-1 production in retinal and brain microvascular endothelial cells, which may contribute to inflammation-related endothelial injury in diseases such as diabetic retinopathy.25914608