| BAMBI |
| LOCUS ID | 25805 | ||||||||||
| GENE_SYMBOL | BAMBI | ||||||||||
| GENE NAME | BMP and activin memb | ||||||||||
| SYNONYMNS | NMA | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 8215 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for sigling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. In isolated glomeruli from biopsies of patients with diabetic nephropathy and in glomeruli from mice with type 2 diabetes, BAMBI was downregulated. | 25576053 |