BCL2
LOCUS ID596
GENE_SYMBOLBCL2
GENE NAMEB-cell CLL/lymphoma 2
SYNONYMNSBcl-2, PPP1R50
CHROMOSOME18
HOMOLOGENE ID527
microRNAsNANA
GENE SUMMARY
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alterte splicing, differ in their C-termil ends. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Accordingly, BCL2 levels were found elevated and caspase-3 and caspase-8 levels decreased in the diabetic group.21983986