BDKRB1
LOCUS ID623
GENE_SYMBOLBDKRB1
GENE NAMEbradykinin receptor B1
SYNONYMNSB1R, BKR1, B1BKR, BKB1R, BDKRB2, BRADYB1
CHROMOSOME14
HOMOLOGENE ID570
microRNAsNANA
GENE SUMMARY
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.We have therefore explored the influence of lack of both bradykinin receptors (B1R and B2R) on diabetic nephropathy, neuropathy, and osteopathy in male mice heterozygous for the Akita diabetogenic mutation in the insulin 2 gene (Ins2)20479236