BDNF
LOCUS ID627
GENE_SYMBOLBDNF
GENE NAMEbrain-derived neurotrophic factor
SYNONYMNSANON2, BULN2
CHROMOSOME11
HOMOLOGENE ID7245
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. Low serum BDNF and higher IL-6 levels are potential risk factors for diabetic retinopathy (DR) in type 2 DM.This study supports the role of BDNF in modulating the pro- and anti-inflammatory cytokines, and low level of BDNF is associated with development of diabetic retinopathy.26004392
Neuropathy1. exogenous BDNF relieved pain symptoms of diabetic rats by reducing hyperexcitability of DRG neurons and might be the potential treatment of painful diabetic neuropathy.26441011