BMP4
LOCUS ID652
GENE_SYMBOLBMP4
GENE NAMEbone morphogenetic protein 4
SYNONYMNSZYME,BMP2B,OFC11,BMP2B1,MCOPS6
CHROMOSOME14
HOMOLOGENE ID7247
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were origilly identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Altertive splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Here, we show that BMP4 may act as an upstream regulatory molecule for the process of extracellular matrix (ECM) accumulation in Diabetic nephropathy (DN) and thereby reveals a new aspect of the molecular mechanisms involved in DN.21471216