| BNIP3 |
| LOCUS ID | 664 | ||||||||||
| GENE_SYMBOL | BNIP3 | ||||||||||
| GENE NAME | BCL2/adenovirus E1B | ||||||||||
| SYNONYMNS | NIP3 | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 2990 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by D methylation. [provided by RefSeq, Dec 2014] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. BNIP3 could therefore serve as a potential drug target against diabetic macrovascular complications and, in particular, DCM | 26170914 |