C3
LOCUS ID718
GENE_SYMBOLC3
GENE NAMEcomplement C3
SYNONYMNSASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p
CHROMOSOME19
HOMOLOGENE ID68031
microRNAsNANA
GENE SUMMARY
C3 (Complement C3) is a Protein Coding gene. Diseases associated with C3 include Complement Component 3 Deficiency, Autosomal Recessive and Hemolytic Uremic Syndrome, Atypical 5. Among its related pathways are Immune response Lectin induced complement pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and C5L2 anaphylatoxin chemotactic receptor binding. An important paralog of this gene is C4B.

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. At different levels of proteinuria, reduced IgG and increased C3 levels were independent indicators of NDRD in T2DM. Insights into these factors will help to advance the clinical management of NDRD.31004313
Nephropathy1. Immunofluorescent staining showed marked IgA and C3 mesangial deposition, weak linear IgG staining of the glomerular basement membrane, and absence of C4 and C1q which was consistent with IgA nephropathy. 30956828
Insulin resistance and inflammation1. Thereby complement links adipose tissue inflammation to systemic metabolic derangements, such as low-grade inflammation, insulin resistance and dyslipidaemia. 25017306