| CAPN10 |
| LOCUS ID | 11132 | |||||||||||||
| GENE_SYMBOL | CAPN10 | |||||||||||||
| GENE NAME | calpain 10 | |||||||||||||
| SYNONYMNS | CANP10, NIDDM1 | |||||||||||||
| CHROMOSOME | 2 | |||||||||||||
| HOMOLOGENE ID | 36323 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domainsdomain I, the N-termil regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large su |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. The fact that the diabetes gene CAPN10 also influences the risk for atherosclerosis shows that inherited factors may underlie the frequent co-occurrence of these two conditions. | 15793266 |
| Dyslipidemia | 1. A genetic variant of the CAPN10 gene in Mexican subjects with dyslipidemia is associated with increased HDL-cholesterol concentrations after the consumption of a soy protein and soluble fiber dietary portfolio. | 25238846 |