CAPN10
LOCUS ID11132
GENE_SYMBOLCAPN10
GENE NAMEcalpain 10
SYNONYMNSCANP10, NIDDM1
CHROMOSOME2
HOMOLOGENE ID36323
microRNAsNANA
GENE SUMMARY
Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domainsdomain I, the N-termil regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-termil domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple altertive transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]

OBSERVATIONS

Complication Evidence PMID
Atherosclerosis1. The fact that the diabetes gene CAPN10 also influences the risk for atherosclerosis shows that inherited factors may underlie the frequent co-occurrence of these two conditions.15793266
Dyslipidemia1. A genetic variant of the CAPN10 gene in Mexican subjects with dyslipidemia is associated with increased HDL-cholesterol concentrations after the consumption of a soy protein and soluble fiber dietary portfolio.25238846