| CARM1 |
| LOCUS ID | 10498 | ||||||||||
| GENE_SYMBOL | CARM1 | ||||||||||
| GENE NAME | coactivator-associat | ||||||||||
| SYNONYMNS | PRMT4 | ||||||||||
| CHROMOSOME | 19 | ||||||||||
| HOMOLOGENE ID | 10990 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Together, our data provide evidence that ubiquitition-dependent CARM1 degradation in podocytes in diabetes promotes podocyte apoptosis via Notch1 activation. Strategies to preserve CARM1 expression or reduce the enzymatic activity of a ubiquitin ligase specific for CARM1 could be used to prevent podocyte loss in diabetic nephropathy. | 24726896 |