| CCKAR |
| LOCUS ID | 886 | ||||||||||
| GENE_SYMBOL | CCKAR | ||||||||||
| GENE NAME | cholecystokinin A re | ||||||||||
| SYNONYMNS | CCK-A, CCKRA, CCK1-R | ||||||||||
| CHROMOSOME | 4 | ||||||||||
| HOMOLOGENE ID | 37337 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Diabetic CCK-1R(-/-),-2R(-/-) mice revealed enhanced albuminuria and inflammation in the kidney compared with diabetic wild type (WT) mice | 22357963 |