CCL20
LOCUS ID6364
GENE_SYMBOLCCL20
GENE NAMEchemokine (C-C motif) ligand 20
SYNONYMNSCKb4, LARC, ST38, MIP3A, MIP-3a, SCYA20, MIP-3-alp
CHROMOSOME2
HOMOLOGENE ID3375
microRNAsNANA
GENE SUMMARY
not availabe

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. KLF6 overexpression increased MIP-3alpha which was inhibited by concurrent exposure to PPAR-gamma agonists. PPAR-gamma agonists attenuated high glucose-induced MIP-3alpha secretion.The recognition of MIP-3alpha as a significant pathogenic mediator in diabetic nephropathy reaffirms the increasingly recognized role of inflammation in the progression of DN.Macrophage inflammatory protein-3 alpha (MIP-3alpha) is known to be upregulated early in the development of diabetic nephropathy (DN).The recognition of MIP-3alpha as a significant pathogenic mediator in diabetic nephropathy reaffirms the increasingly recognized role of inflammation in the progression of DN.21109018