CD163
LOCUS ID9332
GENE_SYMBOLCD163
GENE NAMECD163 molecule
SYNONYMNSM130, MM130
CHROMOSOME12
HOMOLOGENE ID128811
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. The concentrations of sCD163 and periostin in the vitreous were significantly higher in patients with PDR than in non-diabetic controls (p<0.0001)These findings indicate that the overexpression of CD163 by macrophages may be involved in the development of FVMs partly through periostin production.25281471
Atherosclerosis1. Cardiovascular disease is associated with increased sCD163/sTWEAK ratio.26433887
Neuropathy1. Higher levels of soluble CD163 in people with diabetic polyneuropathy suggest that inflammation plays a role in the development of neural impairment. The relationship between cerebrospinal fluid soluble CD163 level and peripheral nerve conduction indicates that soluble CD163 may be a potential biomarker for the severity of diabetic polyneuropathy.25156085