| CD163 |
| LOCUS ID | 9332 | ||||||||||||||||
| GENE_SYMBOL | CD163 | ||||||||||||||||
| GENE NAME | CD163 molecule | ||||||||||||||||
| SYNONYMNS | M130, MM130 | ||||||||||||||||
| CHROMOSOME | 12 | ||||||||||||||||
| HOMOLOGENE ID | 128811 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Retinopathy | 1. The concentrations of sCD163 and periostin in the vitreous were significantly higher in patients with PDR than in non-diabetic controls (p<0.0001)These findings indicate that the overexpression of CD163 by macrophages may be involved in the development of FVMs partly through periostin production. | 25281471 |
| Atherosclerosis | 1. Cardiovascular disease is associated with increased sCD163/sTWEAK ratio. | 26433887 |
| Neuropathy | 1. Higher levels of soluble CD163 in people with diabetic polyneuropathy suggest that inflammation plays a role in the development of neural impairment. The relationship between cerebrospinal fluid soluble CD163 level and peripheral nerve conduction indicates that soluble CD163 may be a potential biomarker for the severity of diabetic polyneuropathy. | 25156085 |